Faculty and staff directory

Iain M. Morgan, Ph.D.

Iain M. Morgan, Ph.D.

Director, Philips Institute for Oral and Craniofacial Molecular Biology

Philips Institute for Oral Health Research
W. Baxter Perkinson Jr. Building
521 North 11th Street
Box 980566
Richmond, Virginia 23298-0566
Phone: (804) 828-0149
Email: immorgan@vcu.edu


Education

  • Ph.D. in Molecular Biology, University of Glasgow, 1989
  • B.Sc. in Biochemistry, University of Strathclyde, 1985

Publications

Donaldson, M.M., Mackintosh, L.J., Bodily, J.M., Dornan, E.S., Laimins, L.A., and Morgan, I.M. (2013)An interaction between human papillomavirus 16 E2 and TopBP1is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology . ISSN 0022-538X(doi:10.1128/JVI.01002-12) (In Press)

Finlay, M., Yuan, Z., Morgan, I.M., Campo, M., and Nasir, L. (2012) Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary Research , 43 . p. 81. ISSN 0928-4249 (doi:10.1186/1297-9716-43-81) 

King, L.E., Dornan, E.S., Donaldson, M.M., and Morgan, I.M. (2011) Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interaction.Virology, 414 (1). pp. 26-33. ISSN 0042-6822 (doi:10.1016/j.virol.2011.03.002)

King, L.E., Fisk, J.C., Dornan, E.S., Donaldson, M.M., Melendy, T., and Morgan, I.M. (2010) Human papillomavirus E1 and E2 mediated DNA replication is not arrested by DNA damage signalling.Virology, 406 (1). pp. 95-102. ISSN 0042-6822 (doi:10.1016/j.virol.2010.06.033 )

Arendt, M. L., Nasir, L., and Morgan, I. M. (2010) The human and canine TERT promoters function equivalently in human and canine cells. Veterinary and Comparative Oncology, 8 (4). pp. 310-316. ISSN 1476-5810 (doi:10.1111/j.1476-5829.2010.00227.x)

Blackford, A.N. et al. (2010) Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proceedings of the National Academy of Sciences of the United States of America, 107 (27). pp. 12251-12256. ISSN 0027-8424 (doi:10.1073/pnas.0914605107)

Arendt, M., Nasir, L., and Morgan, I.M. (2009) Oncolytic gene therapy for canine cancers: teaching old dog viruses new tricks. Veterinary and Comparative Oncology, 7 (3). pp. 153-161. ISSN 1476-5810(doi:10.1111/j.1476-5829.2009.00187.x)

Arendt, M.L., Nasir, L., and Morgan, I.M. (2009) A novel two-step transcriptional activation system for gene therapy directed toward epithelial cells. Molecular Cancer Therapeutics, 8 (12). pp. 3244-3254. ISSN 1535-7163 (doi:10.1158/1535-7163.MCT-09-0543)

Finlay, M., Yuan, Z.Q., Burden, F., Trawford, A., Morgan, I.M., Campo, M.S., and Nasir, L. (2009) The detection of Bovine Papillomavirus type 1 DNA in flies. Virus Research, 144 (1-2). pp. 315-317. ISSN 0168-1702 (doi:10.1016/j.virusres.2009.04.015)

Gobeil, P.A.M., Yuan, Z.Q., Gault, E.A., Morgan, I.M., Campo, M.S., and Nasir, L. (2009) Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts. Virus Research, 145 (1). pp. 162-165. ISSN 0168-1702(doi:10.1016/j.virusres.2009.06.019)

Johansson, C., Graham, S.V., Dornan, E.S., and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394 (2). pp. 194-199. ISSN 0042-6822(doi:10.1016/j.virol.2009.08.046)

Morris, J.S., Nixon, C., King, O.J.A., Morgan, I.M., and Philbey, A.M. (2009) Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ER alpha and p53. Veterinary Journal, 179 (3). pp. 422-429. ISSN 1090-0233 (doi:10.1016/j.tvjl.2007.10.025)

Arendt, M.L., Morris, J., Nasir, L., and Morgan, I.M. (2008) Abstracts presented at the ESVONC spring meeting, Cambridge, UK, 23-25 March 2007. Veterinary and Comparative Oncology, 6 (1). pp. 65-83. ISSN 1476-5810

Morris, J., Nixon, C., Bruck, A., Nasir, L., Morgan, I.M., and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53.Veterinary Journal, 175 (2). pp. 218-226. ISSN 1090-0233 (doi:10.1016/j.tvjl.2007.01.006)

Morris, J.S., Nixon, C., Bruck, A., Nasir, L., Morgan, I.M., and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53. Veterinary Journal, 175 (2). pp. 218-226. ISSN 1090-0233 (doi:10.1016/j.tvjl.2007.01.006 )

Morris, J.S., Nixon, Colin, Bruck, A., Nasir, L., Morgan, I.M., and Philbey, A. (2008)Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ER alpha and p53. Veterinary Journal, 175 (2). pp. 218-226. ISSN 1090-0233(doi:10.1016/j.tvjl.2007.01.006)

Going, J.J., Nixon, C., Dornan, E.S., Boner, W., Donaldson, M.M., and Morgan, I.M. (2007) Aberrant expression of TopBP1 in breast cancer. Histopathology, 50 (4). pp. 418-424. ISSN 0309-0167(doi:10.1111/j.1365-2559.2007.02622.x)

Donaldson, M.M., Boner, W., and Morgan, I.M. (2007) TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin. Journal of Virology, 81 (8). pp. 4338-4342. ISSN 0022-538X(doi:10.1128/JVI.02353-06)

Gobeil, P., Gault, E.A., Campo, M.S., Gow, J., Morgan, I.M., and Nasir, L. (2007) Equine sarcoids are not induced by an infectious cell line. Equine Veterinary Journal, 39 . pp. 189-191. ISSN 0425-1644(doi:10.2746/042516407X179879)

Nasir, L, Gault, E, Morgan, IM, Chambers, G, Ellsmore, V, and Campo, MS (2007) Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids. Virology, 364 . pp. 355-361.(doi:10.1016/j.virol.2007.02.019)